The Association between the Lipids Levels in Blood and Risk of Age-Related Macular Degeneration

卷:8

Wang, Yafeng ; Wang, Mingxu ; Zhang, Xiaoqing ; Zhang, Qianyu ; Nie, Jing ; Zhang, Ming ; Liu, Xiaohong ; Ma, Le

Xi An Jiao Tong Univ

关键词: age-related macular degeneration;    blood lipids levels;    HDL;    meta-analysis;   

DOI  :  10.3390/nu8100663

学科分类：食品科学和技术

【 摘 要 】

Lipid metabolism may be involved in the pathogenic mechanism of age-related macular degeneration (AMD). However, conflicting results have been reported in the associations of AMD with blood lipids. We performed a meta-analysis including a total of 19 studies to evaluate associations between blood lipids and this disease. The result reported that the high level of high-density lipoprotein cholesterol (HDL-C) obtained with an increment of 1 mmol/L could result in a significantly increase in the AMD risk of approximately 18% (relative risk (RR), 1.18; 95% confidence interval (CI), 1.01 to 1.35; I-2 = 53.8%; p = 0.007). High levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG) were significantly associated with a decreased risk of AMD (RRs ranging from 0.92 to 0.95; all p < 0.05). The stratified analysis based on AMD subtypes showed that these blood lipids were only significantly associated with the risk of early AMD (all p < 0.05). The association between the blood lipids and AMD risk did not differ substantially based on the other characteristics of the participants. A high HDL-C level was associated with an increased AMD risk, whereas participants with high TC, LDL-C, and TG concentrations may show a decreased risk for this disease. Further well-designed large studies are warranted to confirm the conclusions.