Nutraceuticals and Their Potential to Treat Duchenne Muscular Dystrophy: Separating the Credible from the Conjecture

卷:8

Woodman, Keryn G. ; Coles, Chantal A. ; Lamande, Shireen R. ; White, Jason D.

Royal Childrens Hosp

关键词: Duchenne muscular dystrophy;    Becker muscular dystrophy;    muscle;    nutraceuticals;    mdx;   

DOI  :  10.3390/nu8110713

学科分类：食品科学和技术

【 摘 要 】

In recent years, complementary and alternative medicine has become increasingly popular. This trend has not escaped the Duchenne Muscular Dystrophy community with one study showing that 80% of caregivers have provided their Duchenne patients with complementary and alternative medicine in conjunction with their traditional treatments. These statistics are concerning given that many supplements are taken based on purely "anecdotal" evidence. Many nutraceuticals are thought to have anti-inflammatory or anti-oxidant effects. Given that dystrophic pathology is exacerbated by inflammation and oxidative stress these nutraceuticals could have some therapeutic benefit for Duchenne Muscular Dystrophy (DMD). This review gathers and evaluates the peer-reviewed scientific studies that have used nutraceuticals in clinical or pre-clinical trials for DMD and thus separates the credible from the conjecture.