The Role of Cytochrome P450 Epoxygenases, Soluble Epoxide Hydrolase, and Epoxyeicosatrienoic Acids in Metabolic Diseases

卷:7

Xu, Xizhen ; Li, Rui ; Chen, Guangzhi ; Hoopes, Samantha L. ; Zeldin, Darryl C. ; Wang, Dao Wen

Huazhong Univ Sci & Technol

关键词: cytochrome P450 (CYP) epoxygenase;    epoxyeicosatrienoic acid;    soluble epoxide hydrolase;    insulin resistance;    lipid;    obesity;    type 2 diabetes;   

DOI  :  10.3945/an.116.012245

学科分类：食品科学和技术

【 摘 要 】

Metabolic diseases are associated with an increased risk of developing cardiovascular disease. The features comprising metabolic diseases include obesity, insulin resistance, hyperglycemia, hyperlipidemia, and hypertension. Recent evidence has emerged showcasing a role for cytochrome P450 epoxygenases, soluble epoxide hydrolase, and epoxyeicosatrienoic acids (EETs) in the development and progression of metabolic diseases. This review discusses the current knowledge related to the modulation of cytochrome P450 epoxygenases and soluble epoxide hydrolase to alter concentrations of biologically active EETs, resulting in effects on insulin resistance, lipid metabolism, obesity, and diabetes. Future areas of research to address current deficiencies in the understanding of these enzymes and their eicosanoid metabolites in various aspects of metabolic diseases are also discussed.