Dietary phosphorus intake is negatively associated with bone formation among women and positively associated with some bone traits among men-a cross-sectional study in middle-aged Caucasians

卷:37

Itkonen, Suvi T. ; Rita, Hannu J. ; Saarnio, Elisa M. ; Kemi, Virpi E. ; Karp, Heini J. ; Karkkainen, Merja U. M. ; Pekkinen, Minna H. ; Laitinen, E. Kalevi ; Risteli, Juha ; Koivula, Marja-Kaisa ; Sievanen, Harri ; Lamberg-Allardt, Christel J. E.

Univ Helsinki

关键词: Phosphorus;    Calcium;    Bone mineral density;    Bone turnover markers;    Peripheral quantitative computed tomography;    Cross-sectional study;   

DOI  :  10.1016/j.nutres.2016.12.009

学科分类：食品科学和技术

【 摘 要 】

High dietary phosphorus (P) intake has acute negative effects on calcium (Ca) and bone metabolism, but long-term clinical data are contradictory. We hypothesized that high P intake is associated with impaired bone health as suggested by earlier short-term studies on bone metabolism. In this cross-sectional study, we investigated associations between dietary P intake, bone traits in the radius and tibia, and bone turnover in a population-based sample of 37- to 47-year-old Caucasian premenopausal women (n = 333) and men (n = 179) living in Southern Finland (60 degrees N). We used various regression models in an "elaboration approach" to elucidate the role of P intake in bone traits and turnover. The addition of relevant covariates to the models mainly removed the significance of P intake as a determinant of bone traits. In the final regression model (P intake, weight, height, age, Ca intake, serum 25-hydroxyvitamin D, physical activity, smoking, contraceptive use in women), P intake was slightly positively associated only with bone mineral content and cross-sectional cortical bone area in the tibia of men. Among women, inclusion of Ca removed all existing significance in the crude models for any bone trait. In women P intake was negatively associated with the bone formation marker serum intact pro-collagen type I amino-terminal propeptide, whereas no association was present between P intake and bone turnover in men. In conclusion, these findings disagree with the hypothesis; P intake was not deleteriously associated with bone traits; however, P intake may negatively contribute to bone formation among women. (C) 2016 Elsevier Inc. All rights reserved.