Elevated levels of pre beta 1-high-density lipoprotein are associated with cholesterol ester transfer protein, the presence and severity of coronary artery disease

卷:16

Bu, Xiao-min ; Niu, Dong-mei ; Wu, Jia ; Yuan, Yun-long ; Song, Jia-xi ; Wang, Jun-jun

Nanjing Univ

关键词: Pre beta 1-HDL;    CETP;    Coronary artery disease;    Atherosclerosis;   

DOI  :  10.1186/s12944-016-0394-1

学科分类：食品科学和技术

【 摘 要 】

Background: Pre beta 1-high-density lipoprotein (pre beta 1-HDL), plays an important role in reverse cholesterol transport and exhibits potent risk for coronary artery disease (CAD). However, the association of plasma pre beta 1-HDL and cholesterol ester transfer protein (CETP) levels in CAD patients and the relationship of pre beta 1-HDL with extent of CAD are debatable. Methods: Pre beta 1-HDL and CETP levels were measured by enzymed-linked immunosorbent assay (ELISAs) in 88 acute coronary syndromes (ACS), 79 stable coronary artery disease (SCAD) patients and 85 control subjects. The correlation analyses, multiple linear regression analyses and logistic regression analyses were performed, respectively. Results: The pre beta 1-HDL and CETP levels in ACS patients were significantly higher than those in SCAD patients and both of them were higher than controls'. Pre beta 1-HDL levels were positively associated with CETP (R = 0.348, P = 0.000), the diameter of stenosis (R = 0.253, P = 0.005), the number of vessel disease (R = 0.274, P = 0.002) and Gensini score (R = 0.227, P = 0.009) in CAD patients. Stepwise multiple linear regression analyses showed that CETP was one of the determinants of pre beta 1-HDL levels. Logistic regression analysis revealed that elevated pre beta 1-HDL and CETP were potential risk factors for both ACS and SCAD. Conclusion: The elevated pre beta 1-HDL levels may change with CETP concentrations in CAD patients and were related to the presence and severity of CAD.