The benefits of omega-3 supplementation depend on adiponectin basal level and adiponectin increase after the supplementation: A randomized clinical trial

卷:34

de Araujo Lima Barbosa, Milena Maria ; Trinanes Raposo, Alexandra Lorenzzi ; Teixeira Damasceno, Nagila Raquel

Univ Sao Paulo

关键词: Fatty acids;    omega-3;    Adiponectin;    Cardiovascular diseases;    Prevention and control;    Risk factors;    Randomized controlled trial;   

DOI  :  10.1016/j.nut.2016.08.010

学科分类：食品科学和技术

【 摘 要 】

Objective: The aim of this study was to analyze whether omega-3 supplementation improves cardiometabolic profile in individuals with cardiovascular risk factors and to determine the effect of adiponectin levels on these changes. Methods: In this double-blind, placebo-controlled, 2-mo clinical trial, we randomized 80 individuals of both sexes (mean age 52 y) with at least one cardiovascular risk factor (excess weight, hypertension, dyslipidemia, diabetes, or smoking) into two groups: omega-3 (supplemented with 3 g/d of fish oil containing 37% eicosapentaenoic acid and 23% docosahexaenoic acid) and placebo (3 g/d of sunflower oil containing 65% linoleic acid). At baseline and after the intervention, we evaluated serum adiponectin, leptin, lipid profile, apolipoproteins (apo), electronegative low-density lipoprotein (LDL[-]), and glucose metabolism (glucose and insulin). Results: After supplementation, the omega-3 group showed an increase in serum adiponectin. After stratifying the omega-3 group by adiponectin concentration at baseline, participants with lower adiponectin concentration showed a higher reduction of total cholesterol, LDL, LDL/high-density lipoprotein ratio, LDL/apo B, and LDL(-). Individuals with a higher variation of adiponectin concentration after omega-3 supplementation presented with reduced blood glucose. The variation of serum adiponectin induced by omega-3 supplementation was negatively correlated with the Framingham and Adult Treatment Panel IV scores (r = -0.4 and P < 0.05 for both). Conclusions: Adiponectin is shown as one of the mechanisms by which omega-3 improves cardiometabolic profile in persons with cardiovascular risk. Moreover, the benefit varies according to the adiponectin basal level and adiponectin variation after supplementation. (C) 2016 Elsevier Inc. All rights reserved.