Use of a novel docosahexaenoic acid formulation vs control in a neonatal porcine model of short bowel syndrome leads to greater intestinal absorption and higher systemic levels of DHA

卷:39

Martin, Camilia R. ; Stoll, Barbara ; Cluette-Brown, Joanne ; Akinkuotu, Adesola C. ; Olutoye, Oluyinka O. ; Gura, Kathleen M. ; Singh, Pratibha ; Zaman, Munir M. ; Perillo, Michael C. ; Puder, Mark ; Freedman, Steven D. ; Burrin, Doug

Beth Israel Deaconess Med Ctr

关键词: Short bowel syndrome;    Intestinal adaptation;    Docosahexaenoic acid;    Fatty acids;    Fat;    Piglet;   

DOI  :  10.1016/j.nutres.2017.02.004

学科分类：食品科学和技术

【 摘 要 】

Infants with short bowel syndrome (SBS) are at high risk for malabsorption, malnutrition, and failure to thrive. The objective of this study was to evaluate in a porcine model of SBS, the systemic absorption of a novel enteral Docosahexaenoic acid (DHA) formulation that forms micelles independent of bile salts (DHA-ALT (R)). We hypothesized that enteral delivery of DHA-ALT (R) would result in higher blood levels of DHA compared to a control DHA preparation due to improved intestinal absorption. SBS was induced in term piglets through a 75% mid-jejunoileal resection and the piglets randomized to either DHA-ALT (R) or control DHA formulation (N = 5 per group) for 4 postoperative days. The median +/- IQR difference in final vs starting weight was 696 +/- 425 gin the DHA-ALT (R) group compared to 132 278 g in the controls (P = .08). Within 12 hours, median IQR DHA and eicosapentaenoic acid plasma levels (mol%) were significantly higher in the DHA-ALT (R) vs control group (4.1 +/- 0.3 vs 2.5 +/- 0.5, P =.009; 0.7 +/- 0.3 vs 0.2 +/- 0.005, P =.009, respectively). There were lower fecal losses of DHA and greater ileal tissue incorporation with DHA-ALT (R) vs the control. Morphometric analyses demonstrated an increase in proximal jejunum and distal ileum villus height in the DHA-ALT (R) group compared to controls (P = .01). In a neonatal porcine model of SBS, enteral administration of a novel DHA preparation that forms micelles independent of bile salts resulted in increased fatty acid absorption, increased ileal tissue incorporation, and increased systemic levels of DHA. (C) 2017 Elsevier Inc. All rights reserved.