Vitamin D and body composition in the elderly

卷:36

Vitezova, Anna ; Muka, Taulant ; Zillikens, M. Carola ; Voortman, Trudy ; Uitterlinden, Andre G. ; Hofman, Albert ; Rivadeneira, Fernando ; Kiefte-de Jong, Jessica C. ; Franco, Oscar H.

Erasmus MC

关键词: 25-Hydroxivitamin D;    Body composition;    Body fat distribution;    The elderly;   

DOI  :  10.1016/j.clnu.2016.04.017

学科分类：食品科学和技术

【 摘 要 】

Objective: To investigate the association between vitamin D status and body composition in the elderly. Methods: This study was embedded in the Rotterdam Study, a population-based prospective study in Rotterdam, the Netherlands, including subjects aged 55 years and older. Serum 25-hydroxyvitamin D (25(OH)D) was measured between 1997 and 1999. Total body fat, android fat, gynoid fat and lean mass were assessed using dual-energy X-ray absorptiometry (DXA) during a follow-up visit after a median time of 5 years (2002-2004). We calculated body fat percentage, lean mass percentage, and android/ gynoid fat ratio. We had 2158 participants included in our analysis. We used multivariable linear regression models. Serum 25(OH)D was analyzed continuously and after categorization according to cutoffs. Results: Mean ( +/- SD) serum 25(OH)D concentration of the study population was 52.6 +/- 25.4 nmol/L. Compared to subjects with an adequate vitamin D status (25(OH)D >= 75 nmol/L), vitamin D deficient participants (25(OH)D < 50 nmol/L) had a higher body fat percentage (beta = 1.29, 95% CI: 0.55, 2.04) whereas no association was found with lean mass (beta = 0.01, 95%Cl: -0.33, 0.35). Lower 25(OH)D was associated with higher total body fat percentage specifically in participants without cardio-metabolic disease. Each 10 unit increase in serum 25(OH)D was associated with 0.03 unit decrease in android fat (beta = -0.03, 95%Cl: -0.06, -0.01); after adjustment for BMI the association was no longer significant. Serum 25(OH)D was also associated with the android/gynoid fat ratio but this was also mainly explained by BMI. Conclusion: Lower serum 25(OH)D concentrations were associated with a higher fat mass percentage. The association between serum 25(OH)D and differential fat distribution in the elderly was mainly explained by BMI and deserves further study. (C) 2016 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.