Comparative assessment of phytochemical profiles, antioxidant and antiproliferative activities of Sea buckthorn (Hippophae rhamnoides L.) berries

卷:221

Guo, Ruixue ; Guo, Xinbo ; Li, Tong ; Fu, Xiong ; Liu, Rui Hai

South China Univ Technol

关键词: Sea buckthorn;    Phytochemicals;    Phenolics;    Antioxidant activity;    Antiproliferative activity;   

DOI  :  10.1016/j.foodchem.2016.11.063

学科分类：食品科学和技术

【 摘 要 】

Phytochemical profiles, antioxidant and antiproliferative activities of berry extracts were evaluated and compared in four subspecies of Sea buckthorn (Hippophae rhamnoides L.). Among the subspecies, Hippophae rhamnoides L. subsp. sinensis exhibited highest total phenolics content (38.7 +/- 1.3 mg GA equiv./g DW) and corresponding total antioxidant activity. Whereas maximum cellular antioxidant and antiproliferative activities were determined in Hippophae rhamnoides L. subsp. yunnanensis. Total antioxidant activity was significantly associated to total phenolics, isorhamnetin-3-rutinoside and isorhamnetin-3-glucoside. The cellular antioxidant activity and antiproliferative activity of phytochemicals were fairly correlated to phenolic acids and flavonoid aglycones. Lower median effective dose (EC50) of individual compounds against human liver cancer HepG2 cells proliferation studies confirmed the better correlation between antiproliferative activity of Sea buckthorn extracts and flavonoid aglycones, including isorhamnetin, quercetin and kaempferol. (C) 2016 Elsevier Ltd. All rights reserved.