Chinese Herbs Interfering with Cancer Reprogramming Metabolism

Evidence-based complementary and alternative medicine: eCAM

Yitao Wang¹  William W. Qiang²  Shengpeng Wang²  Wenan Qiang²  Chunming Wang²  Zhangfeng Zhong²  Haotian Zhang³  Wen Tan⁴ 

[1] Division of Reproductive Science in Medicine, Department of Obstetrics and Gynecology, Feinberg School of Medicine at Northwestern University, Chicago, IL 60611, USA, northwestern.edu;Institute of Chinese Medical Sciences, State Key Laboratory of Quality Research in Chinese Medicine, University of Macau, Macau, umac.mo;School of Pharmacy, Lanzhou University, Lanzhou, Gansu 730000, China, lzu.edu.cn;Yale University, New Haven, CT 06511, USA, yale.edu

DOI  :  10.1155/2016/9282813

学科分类：过敏症与临床免疫学

来源: Hindawi Publishing Corporation

【 摘 要 】

Emerging evidence promotes a reassessment of metabolic reprogramming regulation in cancer research. Although there exists a long history of Chinese herbs applied in cancer treatment, few reports have addressed the effects of Chinese herbal components on metabolic reprogramming, which is a central cancer hallmark involved in the slowing or prevention of chemoresistance in cancer cells. In this review, we have focused on four core elements altered by metabolic reprogramming in cancer cells. These include glucose transport, glycolysis, mitochondrial oxidative phosphorylation, and fatty acid synthesis. With this focus, we have summarized recent advances in metabolic reprogramming of cancer cells in response to specific Chinese herbal components. We propose that exploring Chinese herbal interference in cancer metabolic reprogramming might identify new therapeutic targets for cancer and more ways in which to approach metabolism-related diseases.

【 授权许可】

CC BY