Systems Study on the Antirheumatic Mechanism of Tibetan Medicated-Bath Therapy Using Wuwei-Ganlu-Yaoyu-Keli

BioMed research international

Xing Chen¹  Jing Zhao²  Yi Zhang³  Kehui Zhao³  Jing Wang³  Tianhong Wang³  Jian Yang⁴  Yang Ga⁵ 

[1] Department of Mathematics, Logistical Engineering University, Chongqing, China, hqgc.net;Institute of Interdisciplinary Complex Research, Shanghai University of Traditional Chinese Medicine, Shanghai, China, shutcm.edu.cn;School of National Medicine, Chengdu University of TCM, Chengdu, China, cdutcm.edu.cn;School of Pharmacy, Second Military Medical University, Shanghai, China, smmu.edu.cn;Tibetan Traditional Medical College, Lhasa, China, ttmc.edu.cn

DOI  :  10.1155/2017/2320932

学科分类：基础医学

来源: Hindawi Publishing Corporation

【 摘 要 】

In clinical practice at Tibetan area of China, Traditional Tibetan Medicine formula Wuwei-Ganlu-Yaoyu-Keli (WGYK) is commonly added in warm water of bath therapy to treat rheumatoid arthritis (RA). However, its mechanism of action is not well interpreted yet. In this paper, we first verify WGYK’s anti-RA effect by an animal experiment. Then, based on gene expression data from microarray experiments, we apply approaches of network pharmacology to further reveal the mechanism of action for WGYK to treat RA by analyzing protein-protein interactions and pathways. This study may facilitate our understanding of anti-RA effect of WGYK from perspective of network pharmacology.

【 授权许可】

CC BY