Acidic Polysaccharide from Angelica sinensis Reverses Anemia of Chronic Disease Involving the Suppression of Inflammatory Hepcidin and NF-?B Activation

Oxidative Medicine and Cellular Longevity

Jun Wu¹  Kaiping Wang¹  Fang Cheng¹  Xiao Huang²  Fang Zeng²  Yu Zhang² 

[1] Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Tongji Medical College of Huazhong University of Science and Technology, No. 13, Hangkong Road, Wuhan 430030, China, hust.edu.cn;Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, No. 1277, Jiefang Road, Wuhan 430022, China, hust.edu.cn

DOI  :  10.1155/2017/7601592

学科分类：过敏症与临床免疫学

来源: Hindawi Publishing Corporation

【 摘 要 】

Anemia of chronic disease (ACD) is the second most prevalent anemia and frequently occurs in patients with acute or chronic immune activation. In the current study, we evaluated the therapeutic efficacy of Angelica sinensis polysaccharide (ASP) against ACD in rats and the potential mechanisms involved. The results showed that ASP inhibited inflammatory hepcidin in both HepG2 cells and ACD rats by blocking the IL-6/STAT3 and BMP/SMAD pathways. In ACD rats, the administration of ASP increased ferroportin expression, mobilized iron from the liver and spleen, increased serum iron levels, caused an elevation of serum EPO, and effectively relieved the anemia. Furthermore, ASP inhibited NF-?B p65 activation via the I?B kinases- (IKKs-) I?B? pathway, thereby reducing the secretion of interleukin-6 (IL-6) and TNF-?, which is known to inhibit erythropoiesis. Our findings indicate that ASP is a potential treatment option for patients suffering from ACD.

【 授权许可】

CC BY