Removing Noises Induced by Gamma Radiation in Cerenkov Luminescence Imaging Using a Temporal Median Filter

BioMed research international

Jing Wang¹  Fei Kang¹  Yang Li²  Jimin Liang²  Xu Cao²  Xueli Chen²  Yonghua Zhan² 

[1] Department of Nuclear Medicine, Xijing Hospital, Fourth Military Medical University, Xi’an, Shaanxi 710032, China, fmmu.edu.cn;Engineering Research Center of Molecular and Neuro Imaging, Ministry of Education and School of Life Science and Technology, Xidian University, Xi’an, Shaanxi 710071, China, xidian.edu.cn

DOI  :  10.1155/2016/7948432

学科分类：基础医学

来源: Hindawi Publishing Corporation

【 摘 要 】

Cerenkov luminescence imaging (CLI) can provide information of medical radionuclides used in nuclear imaging based on Cerenkov radiation, which makes it possible for optical means to image clinical radionuclide labeled probes. However, the exceptionally weak Cerenkov luminescence (CL) from Cerenkov radiation is susceptible to lots of impulse noises introduced by high energy gamma rays generating from the decays of radionuclides. In this work, a temporal median filter is proposed to remove this kind of impulse noises. Unlike traditional CLI collecting a single CL image with long exposure time and smoothing it using median filter, the proposed method captures a temporal sequence of CL images with shorter exposure time and employs a temporal median filter to smooth a temporal sequence of pixels. Results of in vivo experiments demonstrated that the proposed temporal median method can effectively remove random pulse noises induced by gamma radiation and achieve a robust CLI image.

【 授权许可】

CC BY