HPV Infection and Prognostic Factors of Tongue Squamous Cell Carcinoma in Different Ethnic Groups from Geographically Closed Cohort in Xinjiang, China

Biochemistry research international

Pan Liu²  Yang Zhang²  Hua Zhang²  Songan Zhang²  Yongxing Bao²  Yiming Reheman²  Lei Zhang²  Huarong Zhao²  Huerxidan Niyaz²  Xinhua Chen³ 

[1]Collaborative Innovation Center for Diagnosis Treatment of Infectious Diseases, 79 Qinchun Road, Hangzhou, Zhejiang 310003, China

[2]First Affiliated Hospital of Xinjiang Medical University, Oncology Center, 137 Liyushan Road, Urumqi 830011, China, xjmu.edu.cn

[3]The Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, Zhejiang University, 79 Qinchun Road, Hangzhou, Zhejiang 310003, China, zju.edu.cn

DOI  :  10.1155/2016/7498706

学科分类：生物化学/生物物理

来源: Hindawi Publishing Corporation

【 摘 要 】

Background. The effect of HPV infection status and ethnic differences on the prognosis of tongue squamous cell carcinoma in Xinjiang presents an interesting set of conditions that has yet to be studied. Methods. A comprehensive analysis of clinical data was undertaken for a cohort consisting of 63 patients with tongue squamous cell carcinoma recruited from three ethnic groups in Xinjiang. PCR was used for the detection of HPV16 and HPV18 infections. Kaplan-Meier survival analysis was used for analyzing survival outcome in addition to the assessment of other prognostic factors. Results. The overall infection rate for HPV was 28.6% (18/63); the 5-year survival rate among the HPV-positive patients was 47.8% and 30.3% for HPV-negative patients. The survival rate for HPV-positive patients who received radiotherapy and chemotherapy was better than for those who did not receive radiotherapy and chemotherapy. N staging and HPV infection were found to be two independent and significant prognostic factors. Conclusion. HPV-positive patients with tongue squamous cell carcinoma are more sensitive to chemotherapy. Higher N staging indicates poor prognosis.

【 授权许可】

CC BY