Obstructive Sleep Apnea, Hypertension, and Their Additive Effects on Atherosclerosis

Biochemistry research international

Mario Francesco Damiani¹  Vito Antonio Falcone¹  Elioda Bega¹  Onofrio Resta¹  Pierluigi Carratù¹  Marco Matteo Ciccone²  Annapaola Zito²  Pietro Scicchitano² 

[1]Institute of Respiratory Disease, University of Bari, Bari, Italy, uniba.it

[2]Section of Cardiovascular Disease, University of Bari, Bari, Italy, uniba.it

DOI  :  10.1155/2015/984193

学科分类：生物化学/生物物理

来源: Hindawi Publishing Corporation

【 摘 要 】

Background and Aims. It is widely accepted that obstructive sleep apnea (OSA) is independently associated with atherosclerosis. Similar to OSA, hypertension (HTN) is a condition associated with atherosclerosis. However, to date, the impact of the simultaneous presence of OSA and HTN on the risk of atherosclerosis has not been extensively studied. The aim of this study was to evaluate the consequences of the coexistence of OSA and HTN on carotid intima-media thickness (IMT) and on inflammatory markers of atherosclerosis (such as interleukin- [IL-] 6 and pentraxin- [PTX-] 3). Methods. The study design allowed us to define 4 groups: (1) controls (n=30); (2) OSA patients without HTN (n=30); (3) HTN patients without OSA (n=30); (4) patients with OSA and HTN (n=30). In the morning after portable monitoring (between 7 am and 8 am), blood samples were collected, and carotid IMT was measured. Results. Carotid IMT, IL-6, and PTX-3 in OSA normotensive patients and in non-OSA HTN subjects were significantly higher compared to control subjects; in addition, in OSA hypertensive patients they were significantly increased compared to OSA normotensive, non-OSA HTN, or control subjects. Conclusions. OSA and HTN have an additive role in the progression of carotid atherosclerosis and in blood levels of inflammatory markers for atherosclerosis, such as interleukin-6 and pentraxin-3.

【 授权许可】

CC BY