The Preclinical Research Progress of Stem Cells Therapy in Parkinson’s Disease

BioMed research international

Xianyun Wang¹  Baoyong Yan¹  Jun Zhang¹  Jing Li¹  Jie Hu¹  Jing Zhang²  Fan Zhang³  Ci Dong⁴  Rui Huang⁵  Pujuan Liu⁶  Xuerui Yu⁷  Quanhai Li⁷  Yixin Qi⁸ 

[1] Cell Therapy Laboratory, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei 050031, China, hebmu.edu.cn;Department of Breast Center, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, China, hebmu.edu.cn;Department of Cardiac Surgery, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei 050031, China, hebmu.edu.cn;Department of General Surgery, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei 050031, China, hebmu.edu.cn;Department of Immunology, Basic Medical College, Hebei Medical University, Shijiazhuang, Hebei 050017, China, hebmu.edu.cn;Department of Neurology, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei 050031, China, hebmu.edu.cn;Department of Paediatrics, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei 050031, China, hebmu.edu.cn;School of Nursing, Hebei Medical University, Shijiazhuang, Hebei, China, hebmu.edu.cn

DOI  :  10.1155/2016/5683097

学科分类：基础医学

来源: Hindawi Publishing Corporation

【 摘 要 】

Parkinson’s disease (PD) is a type of degenerative disorder of the basal ganglia, causing tremor at rest, muscle rigidity hypokinesia, and dementia. The effectiveness of drug treatments gradually diminishes because the conversion to dopamine within the brain is increasingly disrupted by the progressive degeneration of the dopaminergic terminals. After long-term treatment, most patients with PD suffer from disability that cannot be satisfactorily controlled. To solve these issues, stem cells have recently been used for cell therapy of PD. In this review, the characteristics of different stem cells and their therapeutic effects on PD treatment will be discussed.

【 授权许可】

CC BY