Fatal septic shock caused by Paracoccidioides brasiliensis phylogenetic species S1 in a young immunocompetent patient: a case report

Sociedade Brasileira de Medicina Tropical. Revista

Gomes-Silva, Adriano¹  Almeida, Marcos de Abreu¹  Medeiros, Denise Machado¹  Zancopé-Oliveira, Rosely Maria¹  Macedo, Priscila Marques de¹  Almeida-Paes, Rodrigo¹  Da-Cruz, Alda Maria¹  Valle, Antonio Carlos Francesconi do¹  Oliveira Filho, Marcio Amaral de¹  Lima, Jéssica Ribeiro de¹  Coelho, Rowena Alves¹ 

[1] Fiocruz, Rio de Janeiro, Brazil

关键词: Paracoccidioides brasiliensis S1;    Septic shock;    Host-parasite interaction.;   

DOI  :  10.1590/0037-8682-0318-2017

学科分类：农业科学（综合）

来源: Sociedade Brasileira de Medicina Tropical

【 摘 要 】

The authors report the first case of fatal septic shock, a rare clinical presentation of paracoccidioidomycosis (PCM) caused by Paracoccidioides brasiliensis S1. We also provide an immunological evaluation of the patient. Severe clinical signs such as organ dysfunction and digital gangrene occurred in this case. The patient presented a remarkable cell activation profile and diminished percentage of peripheral blood T regulatory cells. A decrease in anti-inflammatory IL-1RA plasma level showed the potential for endothelium damage, probably contributing to a vasculitis process. Together with P. lutzii, P. brasiliensis appears to be involved in severe cases of PCM.

【 授权许可】

CC BY