The therapeutic efficacy of allyl isothiocyanate in cows with bovine digital dermatitis

The Journal of Veterinary Medical Science

Tamako MIYAZAKI¹  Keiji OKADA¹  Kanako CHIBA¹  Masao MIYAZAKI²  Yasushi SEKIYAMA³ 

[1] Cooperative Department of Veterinary Medicine, Faculty of Agriculture, Iwate University, 3-18-8 Ueda, Morioka, Iwate 020-8550, Japan;Department of Biological Chemistry and Food Sciences, Faculty of Agriculture, Iwate University, 3-18-8 Ueda, Morioka, Iwate 020-8550, Japan;Mitsubishi Kagaku Foods Corporation, 1-1-1 Marunouchi, Chiyoda, Tokyo 100-8251, Japan

关键词: allyl isothiocyanate;    bovine digital dermatitis;    non-antibiotic treatment;    treponema;   

DOI  :  10.1292/jvms.16-0270

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

Bovine digital dermatitis (BDD) is the most prevalent infectious cause of lameness in cattle. Because Treponema infection is a major etiology of BDD, the most common treatment of BDD is an antibiotic. Nonetheless, dairy cows require a withdrawal period after antibiotic treatment before their milk can be marketed. To address the problem, in this study, we tested whether 3 nonantibiotic agents (used separately)—allyl isothiocyanate (AITC), sodium alginate, and calcium hydroxide—alleviate BDD lesions in dairy cows. The AITC treatment improved the BDD lesions, whereas the sodium alginate and calcium hydroxide treatments did not. Therapeutic efficacy of AITC was similar to that of lincomycin, a topical antibiotic prescribed for BDD. These results suggest that AITC is a promising nonantibiotic agent for BDD treatment in dairy cows.

【 授权许可】

Unknown