The Journal of Veterinary Medical Science | |
Aminoglycoside resistance of Trueperella pyogenes isolated from pigs in China | |
Hong-Xia MA1  Bo XU1  Ling-Cong KONG1  Wen-Long DONG1  Yu WANG1  Chang-Long GOU1  Yun-Hang GAO1  | |
[1] College of Animal Science and Technology, Jilin Agricultural University, No. 2888 Xincheng Street, Changchun 130118, P.R. China | |
关键词: aminoglycosides; pig; resistance mechanism; Trueperella pyogenes; | |
DOI : 10.1292/jvms.16-0597 | |
学科分类:兽医学 | |
来源: Japanese Society of Veterinary Science | |
【 摘 要 】
We aimed to determine the resistance mechanisms of 27 T. pyogenes isolates from swine in the Jilin province of China. Drug sensitivity analysis indicated that most of the isolated strains were resistant to aminoglycosides. We investigated the genes involved in target alteration, drug inactivation, and increased efflux as potential resistance mechanisms. Two known aminoglycoside resistance genes (aphA1 and strB) were not found in the genomic DNA of any isolate. A 3-bp (CCC) deletion in one 16S rRNA operon was detected in all isolates, and efflux pumps were not active in the resistant group. Ultimately, genes encoding aminoglycoside-modifying enzymes carried by class 1 integrons were identified as the main cause of resistance to aminoglycosides in T. pyogenes.
【 授权许可】
Unknown
【 预 览 】
Files | Size | Format | View |
---|---|---|---|
RO201902198813352ZK.pdf | 767KB | download |