Synthesis and characterization of novel sulfonamides derivatives and theirantimicrobial, antioxidant and cytotoxicity evaluation

Bulletin of The Chemical Society of Ethiopia

关键词: Sulfonamide;    DPPH;    AntiMICrobial activity;   

DOI  :  10.4314/bcse.v31i3.13

学科分类：化学（综合）

来源: Chemical Society of Ethiopia

【 摘 要 】

Five novel sulfonamides derivativesHR5 - HR8andHR14were synthesized by sulfonylation of primary or secondary amine in the presence of base through nucleophilic substitution reaction. Structural elucidation was carried out through FT-IR, UV,1 H NMR, MS and elemental analysis. Prepared compounds were evaluated against pathogenic strains of bacteria ( S. aureusandE. coli ) and fungi ( A. flavousandA. nyger ). Results were compared against standard antifungal and bacterial drug already available in market (isoconazole and sulfmethoxazole). It was found that compoundHR14showed good activity with MIC 1.5 µg/mL and 2.0 µg/mL forS. auruesandE. coli , respectively. WhileHR5showed best antifungal activity with zone of inhibition 27.2+0.12 mm (MIC: 5.25 µg/mL) and 18.1+0.12 mm (MIC: 12.5 µg/mL) againstA. flavousandA. nyger , respectively. Synthesized compounds were also tested for theirin vitroantioxidant activity by using DDPH. Amongst all compoundsHR5was found to have potential activity with 15.60% antioxidant activity at 6 mM concentration.                KEY WORDS : Sulfonamide, DPPH, AntiMICrobial activity Bull. Chem. Soc. Ethiop.2017 , 31(3), 491-498.DOI:http://dx.doi.org/10.4314/bcse.v31i3.13.

【 授权许可】

Unknown