Oftal mokhirurgiya | |
СÐÐТÐÐШÐÐÐЯ ÐÐÐÐ ÐТРÐФÐЧÐСÐÐÐ¥ ФÐÐТÐÐ ÐРРСÐÐÐÐÐÐ ÐÐÐÐÐСТРРÐÐÐÐÐ ÐÐÐ ÐÐÐÐÐ ÐÐÐÐРЫ У ÐÐÐЬÐЫХ С ÐÐÐÐ ÐСТÐÐÐ ÐÐТÐÐ ÐÐТÐÐ | |
Т. Ð. ÐÑÑжкова1  Ð. Ð. ÐÐµÑ Ñ1  Ð. Ð. Шпак2  Ð. Ð. Ðозлова2  | |
[1] ÐÐУ Р«ÐаÑÑно-пÑакÑиÑеÑкий пÑÐ¸Ñ Ð¾Ð½ÐµÐ²ÑологиÑеÑкийÑенÑÑ Ð¸Ð¼ÐµÐ½Ð¸ Ð.Ð. СоловÑева ÐепаÑÑаменÑа здÑÐ°Ð²Ð¾Ð¾Ñ ÑÐ°Ð½ÐµÐ½Ð¸Ñ Ð³. ÐоÑквÑ»;ФÐÐУ «ÐÐТР«ÐикÑÐ¾Ñ Ð¸ÑÑÑÐ³Ð¸Ñ Ð³Ð»Ð°Ð·Ð°Â» имени акад. С.Ð. ФедоÑова» ÐинздÑава РоÑÑии | |
关键词: ciliaryneurotrophic factor; brain-derivedneurotrophic factor; lacrimal fluid; aqueous humor; blood serum; age-related cataract; ÑилиаÑнÑй нейÑоÑÑоÑиÑеÑкий ÑакÑоÑ; нейÑоÑÑоÑиÑеÑкий ÑакÑÐ¾Ñ Ð³Ð¾Ð»Ð¾Ð²Ð½Ð¾Ð³Ð¾ мозга; ÑÐ»ÐµÐ·Ð½Ð°Ñ Ð¶Ð¸Ð´ÐºÐ¾ÑÑÑ; влага пеÑедней камеÑÑ; ÑÑвоÑоÑка кÑови; возÑаÑÑÐ½Ð°Ñ ÐºÐ°ÑаÑакÑа; | |
DOI : 10.25276/0235-4160-2017-1-16-20 | |
学科分类:眼科学 | |
来源: M H T K Mikrokhirurgiya Glaza | |
【 摘 要 】
Purpose . To study a possibility of evaluation of neurotrophic factors content in the aqueous humor (AH) based on a determination of their level in lacrimal fluid (LF) on the examples of ciliary neurotrophic factor (CNTF) and brain-derived neurotrophic factor (BDNF) in patients with age-related cataract. Material and methods . We studied the content of CNTF and BDNF in the LF, AH, and the blood serum (BS) in 55 patients (55 eyes) with agerelated cataract. Collection of stimulated LF was performed with a pipette on the day preceding surgery; the AH and BS were sampled during the phacoemulsification of a cataract. The CNTF and BDNF concentration was measured using an enzyme immunoassay. Results.After the exclusion of patients with outlying (>M+3Ï) values for LF, AH or their ratios, the mean concentration of CNTF in patients was 38.6±17.6 pg/mL in the LF, 55.8±25.0 pg/mL in the AH, and 5.76±5.39 pg/mL in the BS, the concentrations ratio AH / LF was 1.50±0.51. The mean concentration of BDNF in patients was 120.8±42.8 pg/mL in the LF, 49.3±20.8 pg/mL in the AH, and 22270±7040 pg/mL in the BS, the concentrations ratio AH / LF was 0.41±0.13. The concentration of each neurotrophic factor in the AH was correlated with its content in the LF. Pearsonâs correlation coefficient was 0.68 (P<0.000) for CNTF and 0.66 (P<0.000) for BDNF.  Conclusion.   Significant correlations  found between AH and LF levels for both CNTF and BDNF confirm the possibility to use the LF concentration of these neurotrophic factors for an approximate evaluation of their levels in the AH.
【 授权许可】
CC BY
【 预 览 】
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RO201902198119392ZK.pdf | 262KB | download |