Surgical Treatment of Pulmonary Arterial Hypertension

Advances in Pulmonary Hypertension

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关键词: Cardiology;    Pulmonology;    Psychosocial Issues;    Lifestyle Issues;    Social Work;    WHO Group 1- Pulmonary Arterial Hypertension;    WHO Group 3- Pulmonary hypertension owing to lung disease;    /or hypoxia;    PH Medications;    Right Heart Failure;    Pulmonary Function Tests;    Surgical Interventions;    Anatomy;    Physiology/Pathophysiology;    symptoms;    travel;    Cardiopulmonary rehabilitation;    Idiopathic (Primary pulmonary hypertension);    Associated Diseases;    HIV Infection;    Chronic obstructive pulmonary disease (COPD);    bronchiolitis obliterans;    IV therapy;    Inhaled therapy;    Calcium channel blockers;    pharmacokinetics;    nitric oxide;    Diuretics;    Inotropes;    RV Function;    Vasodilator study;    Acute vasodialtor challenge;    Pulmonary vascular resistance;    exercise hemodynamic testing;    Spirometry;    Lung Volumes;    Transplantation;    UNOS Lung Allocation Score;    thromboendarterectomy;    Preserved ejection fraction;    endothelial proliferation;    endothelial dysfunction;    Endothelin;    tricuspid regurgitation;    syncope;    dyspnea;    edema;    hypoxia;    Functional Class;    patient-reported outcomes;    clinical trial endpoints;    biomarkers;    CME;    Angiogram;    Classification;   

DOI  :  

学科分类：医学（综合）

来源: Pulmonary Hypertension Association

【 摘 要 】

Significant advances in the treatment of pulmonary arterial hypertension hav eoccurred in the last several years. The decision to refer a patient for transplantation requires a dynamic approach. Candidate selection and timing of referralto transplant centers is critical for success, particularly with current allocation protocols that do not take into account the severity of illness. Though longterm success is tempered by chronic allograft dysfunction and infection, considerable improvements in outcomes have established lung transplantation for pulmonary arterial hypertension as an efficacious and life-prolonging treatment. However, transplantation should be reserved for patients who have failed the best available medical therapy. Ideally, transplantation occurs when the clinically deteriorating patient has enough reserve to survive long enoughto be transplanted but is not debilitated enough to jeopardize the graft. There is significant uncertainty with regard to this ideal.

【 授权许可】

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