Consciousness loss during epileptogenesis: implication for VLPO-PnO circuits

International Journal of Physiology, Pathophysiology and Pharmacology

Maohui Feng¹ 

关键词: Consciousness loss;    drug-refractory epilepsy;    ventrolateral preoptic area;    nucleus pontis oralis;   

DOI  :  

学科分类：生理学与病理学

来源: e-Century Publishing Corporation

【 摘 要 】

There is a growing concern about consciousness loss during epileptic seizures. Understanding neural mechanisms could lead to a better comprehension of cerebral circuit function in the control of consciousness loss in intractable epilepsy. We propose that ventrolateral preoptic area (VLPO)- PnO (nucleus pontis oralis) circuits may serve a major role in the loss of consciousness in drug-refractory epilepsy. Future behavioural and neuroimaging studies are clearly needed to understand the functional connectivity between the VLPO and PnO during loss of consciousness in drug-refractory epilepsy, to greatly prevent unconsciousness in this disorder and improve the quality of life in patients with intractable epilepsy.

【 授权许可】

CC BY-NC