The effects of prenatal undernutrition and a high-fat postnatal diet on central and peripheral orexigenic and anorexigenic factors in female rats

Endocrine journal

Altankhuu Tungalagsuvd¹  Takeshi Iwasa¹  Minoru Irahara¹  Toshiya Matsuzaki¹  Munkhsaikhan Munkhzaya¹  Yiliyasi Mayila¹  Kiyohito Yano¹  Akira Kuwahara¹ 

[1] Department of Obstetrics and Gynecology, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima 770-8503, Japan

关键词: IUGR;    Hypothalamus;    NPY;    Orexin;    Leptin;   

DOI  :  10.1507/endocrj.EJ16-0593

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

Prenatal undernutrition and postnatal overnutrition increase the risk of some peripheral and central metabolic disorders in adulthood.We speculated that disturbances of appetite/metabolic regulatory factors might already have been established in the early stages of life and contribute to obesity later in life.The effects of a high-fat diet on the levels of peripheral and central appetite/metabolic regulatory factors were compared between the offspring of normally nourished dams and those of undernourished dams in the peri-pubertal period.In the offspring of the normally nourished dams (control), the consumption of the high-fat diet resulted in lower hypothalamic mRNA levels of orexigenic factors (neuropeptide Y (NPY) and prepro-orexin (pporexin)), whereas no such changes were seen in the offspring of the undernourished dams (subjected to intrauterine growth restriction).These results indicate that in high-energy conditions either the adaptive response does not function properly or has not been established in the offspring of undernourished dams.Because NPY and pporexin are negatively regulated by leptin, these findings suggest that in the intrauterine growth restriction group, the leptin resistance of hypothalamic functions, which is usually caused by diet-induced obesity in adulthood, had already been established in the peri-pubertal period.

【 授权许可】

Unknown