Effects of Antrodia camphorata and Panaxginseng supplementation on anti-fatigue properties in mice

The Journal of Veterinary Medical Science

Yu-Tang TUNG¹  Chien-Yu HSIAO²  Chi-Chang HUANG³  City C. HSIEH⁴  Mon-Chien LEE⁴  Yi-Ju HSU⁵ 

[1] Aesthetic Medical Center, Department of Dermatology,Chang Gung Memorial Hospital, Taoyuan 33301, Taiwan;Department of Nutrition and Health Sciences, Chang GungUniversity of Science and Technology, Taoyuan 33301, Taiwan;Graduate Institute of Metabolism and Obesity Sciences,Taipei Medical University, Taipei City 11031, Taiwan;Graduate Institute of Sports Science, National TaiwanSport University, Taoyuan 33301, Taiwan;Research Center for Food and Cosmetic Safety, andResearch Center for Chinese Herbal Medicine, College of Human Ecology, Chang GungUniversity of Science and Technology, Taoyuan 33301, Taiwan

关键词: exercise performance;    fatigue;    lactate;   

DOI  :  10.1292/jvms.17-0572

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

Antrodia camphorata and Panax ginseng are well-knownmedicinal plants in Taiwan folk and traditional Chinese medicine, which have been reportedfor multifunctional bioactivities. However, there is limited evidence that a fixedcombination formula of these two plant extracts is effective for the exercise improvementor anti-fatigue. We aimed to evaluate the potential beneficial effects of the mixformulation of these two herbal medicines (AG formulation) on fatigue and ergogenicfunctions following physiological challenge. Male Institute of Cancer Research (ICR) micefrom four groups (n=10 per group) were orally administered AG formulationfor 4 weeks at 0.984, 2.952 and 5.904 g/kg/day, which were designated the Vehicle, AG-1X,AG-3X and AG-6X groups, respectively. The anti-fatigue activity and exercise performancewere evaluated using exhaustive swimming time, forelimb grip strength, and levels of serumlactate, ammonia, glucose, blood urea nitrogen (BUN) and creatine kinase (CK) after aswimming exercise. The exhaustive swimming time of the 1X, 3X or 6X AG group wassignificantly longer than that of the Vehicle group, and the forelimb grip strength of the1X, 3X or 6X AG group was also significantly higher than that of the Vehicle group. AGsupplementation also produced decreases in serum lactate, ammonia, BUN and CK activityafter the swimming test, as well as increases in glucose. Therefore, the AG complex couldbe a potential formulation with an anti-fatigue pharmacological effect.

【 授权许可】

Unknown