Genetic factors affecting intraoperative 5-aminolevulinic acid-induced fluorescence of diffuse gliomas

Radiology and Oncology

Kiyotaka Saito¹  Hideo Takeshima²  Asya Ivanova²  Shinji Yamashita²  Kiyotaka Yokogami²  Yoshihito Kadota³  Toshinori Hirai³ 

[1] Corresponding authorDepartment of Neurosurgery, Division of Clinical Neuroscience, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan;Department of Neurosurgery, Division of Clinical Neuroscience, Faculty of Medicine, University of Miyazaki, Miyazaki, JapanOther articles by this author:;Department of Radiology, Division of Pathophysiological Diagnosis and Therapy, Faculty of Medicine, University of Miyazaki, Miyazaki, JapanOther articles by this author:

关键词: glioma;    5-aminolevulinic acid (5-ALA);    IDH1 mutation;   

DOI  :  10.1515/raon-2017-0019

学科分类：肿瘤学

来源: Onkoloski Institut Ljubljana / Institute of Oncology Ljubljana

【 摘 要 】

BackgroundIn patients operated for malignant glioma, 5-aminolevulinic acid (5-ALA)-induced fluorescence guidance is useful. However, we occasionally experience instances of non-visible fluorescence despite a histopathological diagnosis of high-grade glioma. We sought to identify factors that influence the intraoperative visualization of gliomas by their 5-ALA-induced fluorescence.

【 授权许可】

Unknown