期刊论文详细信息
Revista Cubana de medicina tropical | |
Some effects of acute and chronic infection with Chagas disease in pregnant Wistar (Rodentia; Muridae) rats | |
Moreno-RodrÃguez, Adriana1  Flores-Villegas, Any Laura2  , José Antonio2  Schlie-Guzmán, MarÃa Adelina3  Gutiérrez-Jiménez, Javier3  DÃaz-Gómez, Jesús3  Vidal-López, Dolores Guadalupe3  | |
[1]Universidad Autónoma Benito Juárez, Oaxaca, México | |
[2]Universidad Nacional Autónoma de México, México | |
[3]Universidad de Ciencias y Artes de Chiapas, Tuxtla Gutiérrez, Chiapas, México | |
DOI : | |
学科分类:传染病学 | |
来源: SciELO | |
【 摘 要 】
Objectives:genetically characterize a strain of Trypanosoma cruzi isolated in thestate of Chiapas, Mexico, and evaluate its effect on gestation in Wistar rats. Methods:evaluation was conducted of the damage caused to gestation in Wistar rats infectedwith the strain ITR/MX/10/COP of T. cruzi, the causal agent ofChagas disease. Two groups of ten female rats were infected intraperitoneallywith 1 x 106 blood trypomastigotes. One group was mated 19 days postinfection(acute stage) and the other 59 days postinfection (chronic stage). Ten non-infectedmated rats were used as control. Before the end of gestation, the rats weresacrificed to estimate the number, weight and length of fetuses, as well asplacenta and umbilical cord measurements.Results:fetuses from the groups infected with T. cruzi showed a significant decreasein number, weight and length (p< 0.05), while placenta and umbilical cordmeasurements were lower in the experimental groups (p< 0.05), but no significantdifferences were found between the groups.Conclusions:acute and chronic infection by T. cruzi in a region of Chiapas, Mexico,characterized as Tcl, may cause considerable damage during gestation.【 授权许可】
CC BY-NC-SA
【 预 览 】
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RO201902196687240ZK.pdf | 153KB | download |