Molecular mechanisms and potentials for differentiating inner ear stem cells into sensory hair cells

Developmental biology

QuanwenLiu¹ 

关键词: Inner ear;    Stem cell;    Hair cell;    Atoh1;    Notch signaling pathway;   

DOI  :  10.1016/j.ydbio.2014.03.010

学科分类：生物科学（综合）

来源: Academic Press

【 摘 要 】

In mammals, hair cells may be damaged or lost due to genetic mutation, infectious disease, chemical ototoxicity, noise and other factors, causing permanent sensorineural deafness. Regeneration of hair cells is a basic pre-requisite for recovery of hearing in deaf animals. The inner ear stem cells in the organ of Corti and vestibular utricle are the most ideal precursors for regeneration of inner ear hair cells. This review highlights some recent findings concerning the proliferation and differentiation of inner ear stem cells. The differentiation of inner ear stem cells into hair cells involves a series of signaling pathways and regulatory factors. This paper offers a comprehensive analysis of the related studies.

【 授权许可】

CC BY