Daruha-yi Giyahi | |
Chemical composition and anti-inflamatory, anti-nociceptive and antipyretic activity of rhizome essential oil of Globba sessiliflora Sims. collected from Garhwal region of Uttarakhand | |
关键词: Globba sessiliflora Sims; Essential oil; Zingiberaceae; β-eudesmol; Anti-inflamatory; Anti-nociceptive; Antipyretic activity; | |
DOI : 10.18869/JHD.2017.59 | |
学科分类:医学(综合) | |
来源: Danishgah-i Azad-i Islami * Shahrekord Branch | |
【 摘 要 】
Background & Aim Family Zingiberaceae is worldwide in  distribution. Plants of the zingiberaceae family are used in traditional  herbal folk medicine besides their uses in spices, cosmetic, ornamental, food  preservatives etc. In Uttarakhand the herbs grow from sub-tropical to  temperate region. Globba sessiliflora Simsrhizomes were collected at maturity stage in November from  Garhwal region of Uttarakhand, India. In present communication the medicinal  use of various zingiberaceous herb provoked us to study the chemical  diversity and pharmacological activity determination of this important  traditional herb. Experimental The essential oil was extracted using hydrodistillation  method and analyzed by GC-MS. Anti-inflamatory, anti-nociceptive and  antipyretic activities of essential oil were experimently determined using  mice model. Results The major compounds identified were β-eudesmol (27.6%), (E)-β-caryophyllene (24.3%), α-humulene  (3.0%), (6E)-nerolidol (4.1%),  caryophyllene oxide (9.7%), γ-eudesmol (6.4%) and Ï-muurolol (8.3%) besides  other minor constituents. Essential oil of G. sessiliflora rhizome showed good anti-inflamatory,  anti-nociceptive and antipyretic activities at the dose level of 100 mg/kg  body weight. The oral administration of the essential oil exhibited no toxicity at 400, 600 and 800 mg/kg  b.wt. concentration. Ibuprofen, indomthacin and paracetamol were used as  standard drugs for comparison. Recommended applications/industries G. sessiliflora essential oil can be used as herbal remedy for its nontoxicityanti-inflamatory, anti-nociceptive and antipyretic activities.
【 授权许可】
CC BY
【 预 览 】
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