Acrolein scavengers, cysteamine and N-benzylhydroxylamine,reduces the mouse liver damage after acetaminophen overdose

The Journal of Veterinary Medical Science

Ryushin MIZUTA¹  Ryo KOYAMA¹ 

[1] Research Institute for Biomedical Sciences, TokyoUniversity of Science, 2669 Yamazaki, Noda, Chiba 278–0022, Japan

关键词: acetaminophen;    acrolein;    cysteamine;    N-benzylhydroxylamine;    oxidative stress;   

DOI  :  10.1292/jvms.16-0325

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

Our previous study suggested that the highly toxic α,β-unsaturated aldehyde acrolein, abyproduct of oxidative stress, plays a major role in acetaminophen-induced liver injury.In this study, to determine the involvement of acrolein in the liver injury and toidentify novel therapeutic options for the liver damage, we examined two putative acroleinscavengers, a thiol compound cysteamine and a hydroxylamineN-benzylhydroxylamine, in cell culture and in mice. Our results showedthat cysteamine and N-benzylhydroxylamine effectively prevented the celltoxicity of acrolein in vitro and acetaminophen-induced liver injuryin vivo, which suggested that acrolein is involved in the liver damage,and these two drugs can be potential therapeutic options for this condition.

【 授权许可】

Unknown