Regulation of type 2 diabetes by helminth-induced Th2 immuneresponse

The Journal of Veterinary Medical Science

Hikaru KADOWAKI¹  Tatsuya ABE¹  Noritsugu AZUMA¹  Yoshiko SUTO¹  Motoko MORIMOTO¹ 

[1] School of Food, Agricultural, and EnvironmentalSciences, Miyagi University, Sendai City, Miyagi 982–0215, Japan

关键词: alternatively activated macrophages;    GLUT2;    steatosis;    type 2 cytokines;    type 2 diabetes;   

DOI  :  10.1292/jvms.16-0183

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

Helminth-induced type 2 cytokines increase the number of regulatory T cells andalternatively activated macrophages, resulting in modulation of the host–immune system.Studies on these parasite-induced immunoregulatory mechanisms might contribute to thedevelopment of new therapies for inflammatory diseases, including type 2 diabetes (T2D).Previous studies have suggested that progression of obesity-associated metabolicabnormalities is under pathophysiological control of CD4+ T cells. Glucose absorptionthrough the intestinal epithelium reduced after infection in a STAT-6-dependent manner. Inthis study, we investigated whether infection with the gastrointestinal nematode parasiteHeligmosomoides polygyrus (Hp) can modulate T2D-associated pathology ina mouse model (KK-Ay/TaJcl). KK-Ay/TaJcl mice were inoculated with infective third-stageHp larvae and studied at Day 8 following infection. Uninfected KK-Ay/TaJcl mice showedhigh blood glucose levels even 120 min after administration of glucose by IP injection.However, it was significantly improved in the infected group. HOMA-IR, fat accumulationand FAS gene expression in the liver were significantly decreased by Hp infection. GLUT2gene expression in this group was significantly lower than that in the uninfected diabeticmice, which might be related to the decrease in glucose absorption in theparasite-infected intestine. In conclusion, helminth-induced type 2 immune responses mightcontribute to T2D disease control.

【 授权许可】

Unknown