Adiponectin deficiency-induced diabetes increases TNFα and FFA viadownregulation of PPARα

The Journal of Veterinary Medical Science

Emika SUGIURA¹  Ri-ichi TAKAHASHI¹  Masafumi YAMAMOTO¹  Motohito GOTO¹  Hiroshi SUEMIZU¹  Haruo HASHIMOTO¹  Hayato ABE¹  Takahiro KAGAWA¹  Toshio AKIMOTO² 

[1] Central Institute for Experimental Animals, 3-25-12Tonomachi, Kawasaki-ku, Kawasaki, Kanagawa 210-0821, Japan;Division of Laboratory Animal Science, Nippon MedicalSchool, 115 Sendagi, Bunkyo-ku, Tokyo 113-8602, Japan

关键词: adiponectin;    diabetes;    PPARα;   

DOI  :  10.1292/jvms.17-0641

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

Expression of peroxisome proliferator-activated receptor (PPAR) α was investigated inadiponectin knockout mice to elucidate the relationship between PPARα and adiponectindeficiency-induced diabetes. Adiponectin knockout (Adp−/−) mice were generatedby gene targeting. Glucose tolerance test (GTT), insulin tolerance test (ITT), and organsampling were performed in Adp−/− mice at the age of 10 weeks. PPARα, insulin,triglyceride, free fatty acid (FFA), and tumor necrosis factor α (TNFα) were analyzed fromthe sampled organs. Adp−/− mice showed impaired glucose tolerance and insulinresistance. Additionally, PPARα levels were decreased and plasma concentration oftriglyceride, FFA and TNFα were increased. These data may indicate that insulin resistancein Adp−/− mice is likely caused by an increase in concentrations of TNFα andFFA via downregulation of PPARα.

【 授权许可】

Unknown