CD133+ cells derived from skeletal muscles of Duchenne muscular dystrophy patients have a compromised myogenic and muscle regenerative capability - ScienceDirect

Stem Cell Research

Jinhong Meng¹ 

关键词: CD133+ cells;    Muscle stem cells;    DMD;    Muscle regeneration;   

DOI  :  10.1016/j.scr.2018.05.004

学科分类：生物科学（综合）

来源: Elsevier

【 摘 要 】

Cell-mediated gene therapy is a possible means to treat muscular dystrophies like Duchenne muscular dystrophy. Autologous patient stem cells can be genetically-corrected and transplanted back into the patient, without causing immunorejection problems. Regenerated muscle fibres derived from these cells will express the missing dystrophin protein, thus improving muscle function.

【 授权许可】

Unknown