AcvR1-mediated BMP signaling in second heart field is required for arterial pole development: Implications for myocardial differentiation and regional identity

Developmental biology

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关键词: Cardiac development;    Second heart field;    Conotruncal defects;    BMP signaling;    Receptors;   

DOI  :  10.1016/j.ydbio.2014.03.008

学科分类：生物科学（综合）

来源: Academic Press

【 摘 要 】

BMP signaling plays an essential role in second heart field-derived heart and arterial trunk development, including myocardial differentiation, right ventricular growth, and interventricular, outflow tract and aortico-pulmonary septation. It is mediated by a number of different BMP ligands, and receptors, many of which are present simultaneously. The mechanisms by which they regulate morphogenetic events and degree of redundancy amongst them have still to be elucidated. We therefore assessed the role of BMP Type I receptor AcvR1 in anterior second heart field-derived cell development, and compared it with that of BmpR1a.

【 授权许可】

CC BY