Insulin-like growth factor 1 receptor expression in advanced non-small-cell lung cancer and its impact on overall survival

Radiology and Oncology

Mojca Humar¹  Vedran Hadzic²  Gregor Vlacic³  Izidor Kern³  Tanja Cufer³ 

[1] Corresponding authorGeneral hospital of Nova Gorica, Ulica padlih borcev 13a, 5290 Šempeter Pri Gorici, Slovenia;Faculty of Sport, University of Ljubljana, Slovenia, Ljubljana, SloveniaOther articles by this author:;University Clinic Golnik, Golnik, SloveniaOther articles by this author:

关键词: insulin-like growth factor 1 receptor;    type 2 diabetes mellitus;    advanced non-small-cell lung cancer;    overall survival;   

DOI  :  10.1515/raon-2017-0020

学科分类：肿瘤学

来源: Onkoloski Institut Ljubljana / Institute of Oncology Ljubljana

【 摘 要 】

BackgroundThe insulin-like growth factor 1 receptor (IGF1R) expression has been addressed as a potential prognostic marker in non-small-cell lung cancer (NSCLC) in various studies; however, the associations between IGF1R expression and prognosis of advanced NSCLC patients is still controversial. The aim of our observational, cohort study was to evaluate the expression of IGF1R in advanced NSCLC and its prognostic role. A subgroup analysis was performed to address the influence of pre-existing type 2 diabetes mellitus (T2DM) status on IGF1R expression and overall survival (OS).

【 授权许可】

Unknown