Pulmonary neuroendocrine tumor in a female wolf (Canis lupus lupus)

The Journal of Veterinary Medical Science

Makoto SHIBUTANI¹  Rei NAGAHARA²  Nanao ITO²  Ayako SHIRAKI²  Hirotada MURAYAMA²  Masahi KAWASHIMA²  Toshinori YOSHIDA³ 

[1] Hirakawa Zoological Park, 5669-1 Hirakawa-cho, Kagoshima-shi, Kagoshima 891-0133, Japan;Laboratory of Veterinary Pathology, Veterinary Science, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu-shi, Tokyo 183-8509, Japan;Pathogenetic Veterinary Science, United Graduate School of Veterinary Sciences, Gifu University, 1-1 Yanagido, Gifu-shi, Gifu 501-1193, Japan

关键词: chromogranin A;    lung;    NCAM (CD56);    neuroendocrine tumor;    wolf;   

DOI  :  10.1292/jvms.16-0490

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

A 17-year-old female wolf (Canis lupus lupus) had a right lung mass that was adhered to the thoracic cavity. Histopathological examination revealed that the mass consisted of sheets, cord or ribbon-like structures of monotonous, small, cuboidal cells with round, oval or short-spindle nuclei and scant clear cytoplasm, demarcated by a fine fibrovascular stroma. Focal necrosis, congestion and thrombi were observed. Immunohistochemically, the tumor cells diffusely expressed cytokeratin AE1/AE3, and some expressed chromogranin A, neural cell adhesion molecule (CD56) and thyroid transcription factor-1. The number of proliferating cell nuclear antigen-positive tumor cells was low. A diagnosis of pulmonary neuroendocrine tumor was based on the resemblance to carcinoids.

【 授权许可】

Unknown