Evaluation of glutathione-binding protein A of Haemophilus parasuis as a vaccine candidate in a mouse model

The Journal of Veterinary Medical Science

Yanhe ZHANG¹  Siguo LIU¹  Gang LI¹  Fang XIE¹  Chunlai WANG¹ 

[1] Division of Bacterial Diseases, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute of Chinese Academy of Agricultural Sciences, Harbin, People’s Republic of China

关键词: Haemophilus parasuis;    glutathione-binding protein A (GbpA);    vaccine candidate;   

DOI  :  10.1292/jvms.16-0327

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

The virulent strains of Haemophilus parasuis are the causative agents of Glässer’s disease, which can cause systemic infection and result in polyserositis, meningitis and arthritis. The development of novel, effective vaccines would be beneficial to preventing H. parasuis infections. Here, we report a novel immunogenic protein, glutathione-binding protein A (GbpA), which can elicit a significant humoral antibody response and confer significant protection against challenge with a lethal dose of a highly virulent H. parasuis strain. The H. parasuis strain can be fully eliminated in the immunized mice. The results indicate that GbpA has the potential to be used as an effective component of a new vaccine against H. parasuis.

【 授权许可】

Unknown