The Journal of Veterinary Medical Science | |
Different allelic frequency of progressive rod-cone degeneration in twopopulations of Labrador Retrievers in Japan | |
Masamine TAKANOSU1  | |
[1] Nasunogahara Animal Clinic, 2-3574-98, Asaka, Ohtawara,Tochigi 342-0043, Japan | |
关键词: allelic frequency; Labrador Retriever; mutation; progressive rod-cone degeneration; | |
DOI : 10.1292/jvms.17-0243 | |
学科分类:兽医学 | |
来源: Japanese Society of Veterinary Science | |
【 摘 要 】
Progressive rod-cone degeneration (PRCD) is an autosomal recessive disease caused byc.5G>A mutation of the PRCD exon 2. This mutation has been identifiedin various breeds, including Labrador Retriever. The present study aimed to examine theallelic frequency of PRCD in Labrador Retrievers in Japan. A domestic and a guide dogpopulation were genotyped for PRCD using polymerase chain reaction-restriction fragmentlength polymorphism. The allelic frequency of c.5G>A in domestic and guide dogpopulations (0.114 and 0.026, respectively) differed significantly. The allele withc.5G>A mutation appeared to spread widely in the domestic population as compared tothat in the guide dog population. This might be the result of mating control for PRCD inthe guide dog population.
【 授权许可】
Unknown
【 预 览 】
Files | Size | Format | View |
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RO201902194541385ZK.pdf | 738KB | download |