Temporal deterioration of neurological symptoms and increase of serumacetylcholine receptor antibody levels after thymectomy: a case report of a cat withmyasthenia gravis

The Journal of Veterinary Medical Science

Tetsushi YAMAGAMI¹  Yumiko KAGAWA¹  Mitsuhiro IRIE²  Hitomi SUZUKI²  Nao NAGATA²  Takuma MIYOSHI²  Yuzo OTAKE² 

[1] North Labo, 8–35 2-chome-kita, Hongo, Shiroishi-ku,Sapporo-shi, Hokkaido 003–0027, Japan;Shikoku Veterinary Medical Center, 3308–5 Ikenobe,Miki-cho, Kida-gun, Kagawa 761–0701, Japan

关键词: acetylcholine receptor antibody;    cat;    myasthenia gravis;    thymectomy;    thymoma;   

DOI  :  10.1292/jvms.16-0134

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

Neurological signs and serum acetylcholine receptor antibody (AChR-Ab) levelsbefore and after thymectomy were monitored in a 6-year-old male cat with acquiredMyasthenia Gravis (MG) as a paraneoplastic syndrome of thymoma. Soon after surgery, theneurological symptoms relapsed, and the cholinesterase inhibitor was administered tocontrol them. The AChR-Ab levels increased postoperatively until 90 days after surgery.This is the first report on long term measurements of serum AChR-Ab levels in a cat withMG. Although thymectomy is valuable for the removal of thymoma, it may not resolve MGsymptoms, neurological signs and serum AChR-Ab levels, without medication early aftersurgery. Also, this case report indicates that the AChR-Ab level might be a guide todetect a deterioration of MG symptoms.

【 授权许可】

Unknown