The relationship between circulating neutrophil gelatinase-associated lipocalin and early alteration of metabolic parameters is associated with dietary saturated fat intake in non-diabetic Korean women

Endocrine journal

Oh Yoen Kim¹  Seongho Han²  Juhyun Song³  So Ra Yoon⁵  Rimkyo Yeo⁵  Ga Yoon Na⁵  Juhyun An⁵  Mi-Na Jo⁶ 

[1] Business Administration, University of Suwon, Suwon 18323, South Korea;Tourism, College of Economics &Department of Biomedical Sciences, Center for Creative Biomedical Scientists at Chonnam National University, Gwangju 61469, South Korea;Department of Family Medicine, Dong-A University, College of Medicine, Busan 49315, South Korea;Department of Food Science and Nutrition, Dong-A University, Brain Busan 21 Project, Busan 49315, South Korea;Division of Hotel &

关键词: Neutrophil gelatinase-associated lipocalin;    Metabolic syndrome;    Saturated fat intake;    Inflammation;    Oxidative stress;   

DOI  :  10.1507/endocrj.EJ16-0233

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

Circulating neutrophil gelatinase-associated lipocalin (NGAL) is associated with obesity-related metabolic disorders.This study investigated the relationship between serum NGAL and early alteration of metabolic parameters in non-diabetic Korean women, particularly with respect to saturated fat (SFA) intake.Anthropometric parameters, fasting glycemic status, and levels of lipids, oxidative stress/inflammatory markers, and NGAL were measured in 82 non-diabetic Korean women [Super-healthy group (n=57) with 0 metabolic syndrome risk factor (MetS RF) and MetS-risk group (n=25) with MetS RF≥1].Age, weight, waist circumference, blood pressure, fasting glucose, HbA1C, triglyceride, LDL and total-cholesterol, and NGAL levels were higher, and HDL-cholesterol was lower in the MetS-risk group than in the Super-healthy group.Age-adjusted serum NGAL levels were higher in the MetS-risk group than in the Super-healthy group.NGAL increased proportionally with increase in MetS RFs (p=0.038) and correlated positively with BMI, triglycerides, LDL- and total-cholesterol, interleukin-6, white blood cell count, and neutrophil%, and negatively with HDL-cholesterol and superoxide dismutase activity.Serum NGAL levels positively correlated with SFA intake before and after adjustment (age and BMI).Serum NGAL levels were higher in high-SFA consumers [≥7g/day, ≥7% of total calorie intake (TCI)] than in low-SFA consumers (<7g/day, <7% of TCI).Serum NGAL levels were highest in the MetS-risk group consuming higher SFA and lowest in the Super-healthy group consuming lower SFA.However, serum NGAL did not significantly differ between the low-SFA consuming MetS-risk and Super-healthy groups.The relationship between circulating NGAL and early alteration of metabolic parameters is associated with dietary SFA intake in non-diabetic Korean women.

【 授权许可】

Unknown