Depression and Pulmonary Arterial Hypertension: Should We be Screening for Depressive Symptoms?

Advances in Pulmonary Hypertension

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关键词: Cardiology;    Psychosocial Issues;    Lifestyle Issues;    Nursing;    Social Work;    WHO Group 1- Pulmonary Arterial Hypertension;    symptoms;    Social Security Disability;    Exercise;    Cardiopulmonary rehabilitation;    nitric oxide;    Diuretics;    Inotropes;    6-Minute Walk Test;    ECMO;    Preserved ejection fraction;    endothelial dysfunction;    dyspnea;    Functional Class;    Exercise capacity;    chest pain;    patient-reported outcomes;    Drug development;    clinical trial endpoints;    REVEAL;    CME;    CEU;    Classification;    Epidemiology;    Screening;   

DOI  :  

学科分类：医学（综合）

来源: Pulmonary Hypertension Association

【 摘 要 】

In genetically susceptible patients, portal hypertension is hypothesized to create a metabolic environment promoting the development of a pulmonary arterial vasculopathy, pathologically indistinct from idiopathic pulmonary arterial hypertension.4 Such pathology includes endothelial/smooth muscle proliferation, in-situ thrombosis, and vasoconstriction.5 The presence of any degree of POPH correlates poorly with the cause or severity of liver disease as measured by the Child-Turcotte-Pugh or Model for End-stage Liver Disease scoring systems. POPH appears to be more frequent in females and patients with autoimmune-related liver disease.6 Portopulmonary hypertension portends a poor prognosis without medical treatment (5-year survival 14%).

【 授权许可】

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