Flavonoids screening and hypoglycemic effect of Genista quadriflora Munby in alloxan-induced diabetic rats

Der Pharmacia Lettre

N. Baali¹ 

关键词: N. Baali;    Z. Belloum;    S. Ameddah;    A. Menad F. Benayache;    S. Benayache;    Genista quadrifloraMunby;    flavonoids;    Antidiabetic effect;    Alloxan;    antioxidant;   

DOI  :  

学科分类：药理学

来源: Scholars Research Library

【 摘 要 】

The aim of this study was to investigate the hypoglycemic activities of the n-butanolic extract of Genista quadriflora Munby (GQBE) in both normal and diabetic rats. Our results revealed that the GQBE (100 mg/Kg, 150 mg/Kg) reduce blood glucose levels in normal as well as alloxan (150 mg/Kg) induced diabetic rats in a time and dose dependent manner, the maximum reduction was recorded at 14th day. The anti-diabetic effect of GQBE was also associated with the amelioration of alloxan altered parameters. GQBE has proved a good prevention of liver glycogen depletion, good restoration of ALT, AST andHb levels. GQBE with a large amount of flavonoids was found to possess a potent antioxidant activity (OH° scavenging and Iron chelating effect). Based on these results, we can speculate that GQBE exhibit a good diabetic management and couldbe an effective alternative therapy for diabetic patients.

【 授权许可】

CC BY