Royal jelly improves hyperglycemia in obese/diabetic KK-Aymice

The Journal of Veterinary Medical Science

Daiki SASAKI¹  Risa WATADANI¹  Kozo MATSUMOTO¹  Akihiko MAEDA¹  Keiya TANIMURA¹  Mei YOSHIDA¹  Kaori HAYASHI¹  Yoshiyasu OKANO¹  Jun KOTOH¹ 

[1] Department of Animal Medical Sciences, Faculty of LifeSciences, Kyoto Sangyo University, Motoyama, Kamigamo, Kita-ku, Kyoto 603-8555,Japan

关键词: diabetes;    hyperglycemia;    KK-Ay mice;    royal jelly;   

DOI  :  10.1292/jvms.16-0458

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

The study examined whether royal jelly (RJ) can prevent obesity and amelioratehyperglycemia in type 2 diabetes. This study utilized obese/diabetic KK-Ay mice. RJ (10mg/kg) was administered by oral gavage. Body weight, plasma glucose and insulin levelswere measured. mRNA and protein levels were determined using quantitative reversetranscription polymerase chain reaction and western blotting, respectively. Four weeks ofRJ administration improved hyperglycemia and partially suppressed body weight gain,although the latter effect did not reach statistical significance. In addition, RJadministration did not improve insulin resistance. RJ administration suppressed the mRNAexpression of glucose-6-phosphatase (G6Pase), a key enzyme ofgluconeogenesis, in the liver. Simultaneously, RJ administration induced adiponectin(AdipoQ) expression in abdominal fat, adiponectin receptor-1(AdipoR1) expression in the liver and phosphorylated AMP-activatedprotein kinase (pAMPK) expression, which suppressed G6Pase levels in the livers of KK-Aymice. pAMPK levels were also increased in skeletal muscle, but glucose transporter-4(Glut4) translocation was not increased in the RJ supplementation group. The improvementin hyperglycemia due to long-term RJ administration may be because of the suppression ofG6Pase expression through the upregulation of AdipoQ andAdipoR1 mRNA and pAMPK protein expressions.

【 授权许可】

Unknown