Development and evaluation of in situ gelling system for treatment of periodontitis

Der Pharmacia Lettre

Khushbu S. Patel¹ 

关键词: Khushbu S. Patel;    K. R. Vadalia;    J. K. Patel;    In situ gel;    Periodontitis;    Carbopol 934;    pH sensitive;   

DOI  :  

学科分类：药理学

来源: Scholars Research Library

【 摘 要 】

Tinidazole is well reported for the treatment of periodontal disease, they have better penetration into periodontal tissues, minimal bacterial resistance as compared to many of the other drugs used for the treatment. In situ gelforming systems are viscous liquids that shift to a gel phase upon exposure to physiological conditions. Tinidazole periodontal gel was prepared by different concentrations of Carbopol 934 (pH sensitive). All the prepared formulations were evaluated for appearance, pH, viscosity, Gelling capacity, % drug content, syringeability, % drug release and effect of sterilization. By compatibility study drug was found to be compatible with formulation excipients. pH and Viscosity of all prepared formulations was found in the range of 3.34- 3.89 and 310-692 centipoise respectively. All the formulations except C7 and C8 show satisfactory syringeability. The developed formulations showed satisfactory results for pH, viscosity, Drug content, in-vitro gelling capacity, rheology and other physical properties. Based on maximum desirability and cost effectiveness formulation containing 0.6% carbopol 934 was considered as an optimized batch.

【 授权许可】

CC BY