Comparative toxicity of dinophysistoxin-1 and okadaic acid inmice

The Journal of Veterinary Medical Science

Yumiko OKADA¹  Hodaka SUZUKI² 

[1] Division of Biomedical Food Research, NationalInstitute of Health Sciences, 3-25-26 Tonomachi, Kawasaki-ku, Kawasaki-shi, Kanagawa210-9501, Japan;Laboratory of Food Microbiology and Toxicology, Collegeof Agriculture, Ibaraki University, 3-21-1 Chuo, Ami, Inashiki, Ibaraki 300-0393,Japan

关键词: diarrhetic shellfish poisoning (DSP) toxin;    dinophysistoxin-1 (DTX-1);    mouse bioassay;    okadaic acid (OA);    survival curve;   

DOI  :  10.1292/jvms.17-0377

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

The mouse bioassay for diarrhetic shellfish poisoning toxins has been used worldwide. Inthis study, dinophysistoxin-1 (DTX-1) and okadaic acid (OA) were compared for toxicity.The lethality rate increased and the median survival time decreased in a dose-dependentmanner in both DTX-1 and OA. The median lethal dose value was 150.4 µg/kg(95% confidence interval=130.1–171.2 µg/kg) for DTX-1 and 185.6µg/kg (95% confidence interval=161.2–209.6 µg/kg) forOA. The toxicity equivalent factor 11 has been used for OA and DTX-1 in the EU and Japan.Thus, it may be considered that toxicity potential of DTX-1 has remained underestimated ascompared to that of OA and DTX-1 might be more toxic than OA.

【 授权许可】

Unknown