Multicentric plasmacytoma in a harbor porpoise Phocoena phocoena off the coast of Whidbey Island, Washington State, USA

Diseases of Aquatic Organisms

Barry H. Rickman¹ 

关键词: Cancer;    Neoplasia;    Cetacean;    Harbor porpoise;    Multicentric anaplasmic plasmacytoma;    Phocoena phocoena;    Marine mammal;   

DOI  :  10.3354/dao03204

学科分类：生物科学（综合）

来源: Inter-Research

【 摘 要 】

ABSTRACT: Necropsy of a female adult pregnant harbor porpoise Phocoena phocoena revealed a multicentric plasmacytoma. The plasmacytoma infiltrated the cranial lung lobes, mediastinal lymph nodes and the spleen. Diagnosis was based on gross, histopathologic and immunohistochemical studies. Histopathology revealed a diffuse proliferation of atypical pleomorphic neoplastic round cells with plasmacytic features. Positive immunohistochemistry with anti-CD79a and anti-CD20 antibody markers and anti-multiple myeloma oncogene 1 (MUM-1) for plasmacytoma confirmed this neoplasm to be of B-cell origin. This is the first recorded case of a plasmacytoma in a harbor porpoise. Routine viral screening was negative via standard PCR for herpesvirus and reverse transcriptase PCR for morbillivirus. Retroviral screening was not performed.

【 授权许可】

Unknown