Evaluation of total intravenous anesthesia withpropofol-guaifenesin-medetomidine and alfaxalone-guaifenesin-medetomidine in Thoroughbredhorses undergoing castration

The Journal of Veterinary Medical Science

Shun-ichi NAGATA¹  Asuka KUSHIRO²  Ai WAKUNO²  Masashi KAKIZAKI²  Motoki AOKI²  Naomi MAE²  Minoru OHTA² 

[1] Laboratory of Racing Chemistry, Tochigi 320-0851,Japan;Racehorse Clinic, Miho Training Center, Japan RacingAssociation, Ibaraki 300-0493, Japan

关键词: alfaxalone;    horse;    propofol;    TIVA;   

DOI  :  10.1292/jvms.16-0658

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

Anesthetic and cardiorespiratory effects of total intravenous anesthesia (TIVA) techniqueusing propofol-guaifenesin-medetomidine (PGM) and alfaxalone-guaifenesin-medetomidine(AGM) were preliminarily evaluated in Thoroughbred horses undergoing castration. Twelvemale Thoroughbred horses were assigned randomly into two groups. After premedication withintravenous (IV) administrations of medetomidine (5.0 µg/kg) andbutorphanol (0.02 mg/kg), anesthesia was induced with guaifenesin (10 mg/kg IV), followedby either propofol (2.0 mg/kg IV) (group PGM n=6) or alfaxalone (1.0 mg/kg IV) (groupAGM n=6). Surgical anesthesia was maintained for 60 min at a constant infusion of eitherpropofol (3.0 mg/kg/hr) (group PGM) or alfaxalone (1.5 mg/kg/hr) (group AGM), incombination with guaifenesin (80 mg/kg/hr) and medetomidine (3.0µg/kg/hr). Responses to surgical stimuli, cardiorespiratory values, andinduction and recovery characteristics were recorded throughout anesthesia. Duringanesthesia induction, one horse paddled in group PGM. All horses from group AGM weremaintained at adequate anesthetic depth for castration. In group PGM, 3 horses showedincreased cremaster muscle tension and one showed slight movement requiring additional IVpropofol to maintain surgical anesthesia. No horse exhibited apnea, although arterialoxygen tension decreased in group AGM to less than 60 mmHg. Recovery quality was good toexcellent in both groups. In conclusion, TIVA using PGM and AGM infusion was available for60 min anesthesia in Thoroughbred horses. TIVA techniques using PGM and AGM infusionprovided clinically acceptable general anesthesia with mild cardiorespiratory depression.However, inspired air should be supplemented with oxygen to prevent hypoxemia duringanesthesia.

【 授权许可】

Unknown