Careful readings for a flash glucose monitoring system in nondiabetic Japanese subjects: individual differences and discrepancy in glucose concentrarion after glucose loading [Rapid Communication]

Endocrine journal

Yoshihiko Sato¹  Atsuko Kaneko¹  Masanori Yamazaki¹  Keiko Sekido¹  Manami Hosokawa¹  Ai Sato¹  Takashi Sekido¹  Mitsuhisa Komatsu² 

[1] Department of Diabetes, Endocrinology and Metabolism, Division of Internal Medicine, Shinshu University School of Medicine, Matsumoto, Japan;Department of Drug Discovery Science, Shinshu University School of Medicine, Matsumoto, Japan

关键词: Flash glucose monitoring;    Interstitial fluid glucose;   

DOI  :  10.1507/endocrj.EJ17-0193

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

The FreeStyle Libre Flash Glucose Monitoring System (FGM), which can continuously measure glucose concentration in the interstitial fluid glucose (FGM-ISFG), has been in clinical use worldwide.However, it is not clear how accurately FGM-ISFG reflects plasma glucose concentration (PG).In the present study, we examined the clinical utility of FGM by oral glucose tolerance test (OGTT).In eight healthy volunteers (3 males; mean age, 41.8 y) wearing FGM sensors for 14 days, OGTT was performed during days 1-7 and days 8-14, and then both FGM-ISFG and PG were compared.Parkes error grid analysis indicated that all of 65 FGM-ISFG values were within Zone A (no effect on clinical action) and Zone B (little or no effect on clinical outcome).However, in OGTT, the mean FGM-ISFG was higher than the mean actual PG at 30, 60, and 90 minutes after loading (155.5 vs. 139.2 mg/dL, 166.2 vs. 139.2 mg/dL, 149.5 vs. 138.2 mg/dL, respectively; p<0.05).Moreover, the area under the curve of FGM-ISFG was also significantly larger than that of PG (17,626.2 vs. 15,195.0 min·mg/dL; p<0.05).In four of eight subjects, FGM-ISFG tended to be higher than PG in both OGTTs, and the greatest difference between the two values was 58 mg/dL.FGM is useful for glycemic control, whereas it is not appropriate to change therapeutic regimens based on the judgment of nocturnal hypoglycemia and postprandial hyperglycemia by FGM-ISFG.Careful attention is required for proper application of FGM.

【 授权许可】

Unknown