Retrospective analysis of canine gallbladder contents in biliary sludge andgallbladder mucoceles

The Journal of Veterinary Medical Science

Benedict Huai Ern ONG¹  Kiyokazu NAGANOBU²  Shidow TORISU²  Yasuyuki KANEKO²  Shushi YAMAMOTO²  Shinya MIZUTANI²  Shinsuke FUJIMOTO² 

[1] Ozu Animal Clinic, 317 Muro, Ozu Town, KikuchiDistrict, Kumamoto 869-1235, Japan;University of Miyazaki Veterinary Teaching Hospital,1-1 Gakuen Kibana-dai Nishi, Miyazaki City, Miyazaki 889-2192,Japan

关键词: biliary sludge;    dog;    gallbladder mucocele;    infrared spectroscopy;    mucin;   

DOI  :  10.1292/jvms.16-0562

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

The pathophysiology of canine gallbladder diseases, including biliary sludge, gallbladdermucoceles and gallstones, is poorly understood. This study aimed to evaluate the componentof gallbladder contents and bacterial infection of the gallbladder in order to elucidatethe pathophysiology of biliary sludge and gallbladder mucoceles. A total of 43 samples ofcanine gallbladder contents (biliary sludge, 21 and gallbladder mucoceles, 22) weresubjected to component analysis by infrared spectroscopy, and the resultant infraredspectra were compared with that of swine mucin. Of the 43 samples, 41 were also evaluatedby aerobic and anaerobic bacterial culture. The contents of 20 (95.2%) biliary sludge and22 (100%) gallbladder mucocele samples exhibited similar infrared spectra as swine mucin.Although biliary sludge and gallbladder mucocele contents exhibited similar infraredspectra, one sample of biliary sludge (4.8%) was determined to be composed of proteins.The rate of bacterial infection of the gallbladder was 10.0% for biliary sludge and 14.3%for gallbladder mucoceles. Almost all of the identified bacterial species were intestinalflora. These results indicate that the principal components of gallbladder contents inboth gallbladder mucoceles and biliary sludge are mucins and that both pathophysiologiesexhibit low rates of bacterial infection of the gallbladder. Therefore, it is possiblethat gallbladder mucoceles and biliary sludge have the same pathophysiology, and, ratherthan being independent diseases, they could possibly represent a continuous disease. Thus,biliary sludge could be considered as the stage preceding the appearance of gallbladdermucoceles.

【 授权许可】

Unknown