Formulation and evaluation of zolmitriptan fast dissolving buccal films

Der Pharmacia Lettre

S. Vidyadhara¹ 

关键词: S. Vidyadhara*;    T. Balakrishna;    R. L. C. Sasidhar;    Ch. Showri Babu;    D. Lakshmi Harika;    Buccal films;    Zolmitriptan;    Polyvinyl alcohol;    polyvinyl pyrrolidone;    Solvent evaporation method;   

DOI  :  

学科分类：药理学

来源: Scholars Research Library

【 摘 要 】

The present study deals with the formulation of fast dissolving buccal films of Zolmitriptan which is used for the treatment of Migraine. The concept of fast dissolving drug delivery emerged from the desire to provide patient with more conventional means of taking their medication. In the present research work polyvinyl alcohol and polyvinyl pyrrolidine were used as film forming agents. Solvent evaporation method was used for the preparation of films. The prepared films were evaluated for film thickness, folding endurance, dispersion test, drug content and dissolution. The In vitro dissolution studies were carried out using simulated salivary fluid (pH 6.8 phosphate buffer). Formulation FP7 released 99% of the drug from the film within 5 minutes which is an essential character for faster absorption and also exhibited all desirable characteristics of the film..

【 授权许可】

CC BY